RESEARCH TOPICS

1. Pathomechanisms of pituitary dysfunction in sheep – in vivo and in vitro study.  
2. Disorders in leptin action and in the expression of leptin receptors in pituitary cells in the pathogenesis of ovarian cysts in sheep.  
3. The relationship between KiSS-10 and ovarian steroid hormones in the pathogenesis of the follicular cysts in cows.  
4. Prenatal and postnatal programming of the puberty rate in sheep.  
5. The role of leptin and KiSS-1/GPR54 system in the pathogenesis of the delayed puberty in ewe lambs.
6. The proliferative activity and differentiation processes of cancer stem cells during rat hepatocarcinogenesis.
7. Analysis of caspase-dependent and receptor interacting protein kinase-dependent (RIP-1 and RIP-3) molecular mechanisms of the programmed cell death of neoplastic oval cells and factors responsible for inducing this process.
8. The contribution of hepatic stellate cells (HSC) and Kupffer cells in the inflammatory process in the course of liver fibrosis and hepatocarcinogenesis.
9. The influence of dietary cation-anion difference (DCAD) on performance, weight gain, blood acid-base balance and bone mineralization in growing turkeys.
10. The proliferative activity of lymphocytes isolated from animals suffered from inflammatory disorders (BRD, mastitis, metritis).
11. The assessment of neutrophil secretory activity as well as their destructive inflammatory response in the course of respiratory and reproductive system disorders in different animal species.
12. Coagulopathies and relations between coagulation system and inflammation in diseases of cattle and dogs.
13. The influence of the activity of skeletal muscles on myokines release as an indicators of transport effort in horses.
14. The impact of isolated cathelicidins on neutrophils in the course of implantation of biomaterial into the bone defect.
15. The importance of cathelicidins as peptides involved in modulating the inflammatory response in various animal species.

Grant projects realised in recent years

• „Assesment of therapeutic suitability of oval cells in liver damage in rats”; (N N3083169 33; 2007-2010); grant manager: prof. dr hab. Ryszard Bobowiec
• „ Prenatal and postnatal programming of puberty rate in sheep and its effect on leptin level and KiSS-1/GPR54 expression in anterior pituitary” (N N308 598439; 2010-2013); grant manager: dr hab. Urszula Kosior-Korzecka
• „Modification of hepatic neoplasia induced of the monocytic/ macrophagic system in rats and humans”(UMO-2014/15/B/NZ5/01587; 2015-2018); grant manager: dr Marta Wójcik