Person responsible for subject:

dr Angelika Tkaczyk-Wlizło
phone: # 48 81 445 67 92
mail:
Institute of Biological Basis of Animal Production,
Akademicka St. 13, Collegium Zootechnicum,
1st floor, room 214

The aim of teaching „genetic modifications and gene therapy” is to acquaint students with genetic modifications, selected molecular techniques and manipulations carried out on DNA. Also, current research trends and achievements in the field of genetic engineering, with particular emphasis on gene therapy will be presented.

Topics of planned classes:

1. Introduction of advanced molecular biology. Genetic modifications of DNA.
2. Molecular techniques used in genetic engineering (e.g. transgenesis, somatic cloning) and their application areas.
3. Gene therapy – from begging to now. Plasmid, viral and non-viral vectors.
4. Examples of genetically modified organisms. The use of transgenic organisms in human and veterinary medicine. Transgenic animals as bioreactors.
5. CRISPR technique – possibilities and threats.
6. Problems and achievements of gene therapy. Gene therapy of hereditary monogenic diseases and acquired diseases. Legal regulations regarding genetic modifications in Poland and the European Union. Perspectives related to genetic manipulations and gene therapy.
7. Student’s presentations of selected topics and discussion. Summary of described topics.
8. Written test

Literature:

1. Brown T. A. Genomes. Wydawnictwo Naukowe PWN. 2019.
2. Brown T. A. Gene Cloning and DNA Analysis: An Introduction. Wiley-Blackwell. 2013.
3. Mauro G. Gene Therapy. Springer. 2010.

Methods of verification forms of the achieved learning outcomes:

1. Presentation of prepared projects, participation in the discussion.
2. Written test.